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Abstract
We undertook this review to propose a minimum set of standards with which any evaluation
of pharmacotherapy should comply, to review the evidence on which the relative risks
of calcium channel blocker therapy for hypertension are based, and to evaluate published
studies against these proposed standards. We selected English-language primary study
reports published in peer-reviewed biomedical journals between 1995 and 1997. All
the reviewed studies suffer from either possible misclassification of antihypertensive
drug therapy, mismeasurement of drug exposure, or both. Given the inadequate documentation
of subjects' drug therapy, resulting relative risk estimates cannot be substantiated.
Keywords
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© 1998 Published by Elsevier Inc.
