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Abstract
The use of topical corticosteroids has significantly enhanced the treatment of patients
with dermatoses such as psoriasis and eczema. In particular, group I high-potency
corticosteroids such as clobetasol propionate have proved safe and effective for limited-course
treatment of inflammatory and pruritic manifestations of moderate-to-severe corticosteroid-responsive
dermatoses. At the same time, much effort has gone into devising more effective strategies
for addressing the dry skin conditions associated with various dermatologic disorders.
An emollient added to a steroid, although not itself an active ingredient, can help
restore the normal moisturizing process of the skin; this may be particularly important
in soothing the discomfort of the dry skin conditions often encountered in moderate-to-severe
dermatoses. In addition, the degree of epidermal hydration can affect the penetration
of steroids into the skin. Therefore, successful outcomes in the treatment of patients
with corticosteroid-responsive dermatoses may involve more than use of an effective
topical steroid. This article examines a currently available cream formulation of
0.05% clobetasol propionate containing moisturizers—emollients, dimethicone, and a
humectant—that may contribute to improved moisture content in treated skin. A review
of recent studies shows that clobetasol propionate emollient cream is well tolerated
and effective in courses of up to 4 weeks for the treatment of patients with psoriasis
or atopic dermatitis
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© 1998 Published by Elsevier Inc.
