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Abstract
The effects of long-term monotherapy with doxazosin, an alpha1-blocker, or placebo on blood pressure (BP), glucose tolerance, and serum lipid levels
were investigated prospectively in 43 hypertensive patients with impaired glucose
tolerance. The levels of plasma glucose, serum lipids, fructosamine, and glycated
hemoglobin A1c (Hb A1c) were determined before and during long-term (mean treatment period, 6.7 months)
therapy with doxazosin (n = 23) or placebo (n = 20). A 75-g oral glucose tolerance
test was performed before and during therapy. Significant decreases in both systolic
and diastolic BP were maintained during doxazosin therapy; BP did not change in the
placebo group. Neither fasting nor post—glucose-load venous plasma glucose levels
were altered, and there was no significant change in the insulinogenic index in either
group. Glucose intolerance was slightly improved with significant reductions in Hb
A1c and fructosamine levels during doxazosin therapy. Serum total cholesterol (TC) and
low-density lipoprotein (LDL) cholesterol levels were significantly decreased, and
high-density lipoprotein cholesterol levels were significantly increased in patients
treated with doxazosin. Moreover, TC, LDL cholesterol, and apolipoprotein B levels
were significantly decreased in patients with hypercholesterolemia (TC ≥5.69 mmol/L).
In contrast, there were no significant changes in Hb A1c, fructosamine, and lipid levels in the placebo group. These results suggest that
long-term doxazosin therapy may improve glucose and lipid metabolism in hypertensive
patients. Doxazosin appears useful as an antihypertensive agent for hypertensive patients
with either impaired glucose metabolism or dyslipidemia.
Keywords
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© 1997 Published by Elsevier Inc.
