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Abstract
The effects of 4 weeks of treatment with doxazosin or enalapril on diastolic blood
pressure (DBP) and plasma lipid levels were studied in 160 patients 18 to 50 years
old with mild-to-moderate hypertension. Comparing baseline measurements with measurements
taken after 4 weeks, DBP was significantly reduced by 6.8 ± 7.4 (mean ± SD) mm Hg
and 12.0 ± 7.1 mm Hg in the doxazosin and enalapril groups, respectively. Systolic
blood pressure was significantly decreased from baseline to end of treatment in both
groups. There were no significant changes in heart rate from baseline to end of treatment
in the doxazosin group, but there was a statistically significant decrease in heart
rate in the enalapril group. High-density lipoprotein cholesterol increased statistically
significant in the doxazosin group but not in the enalapril group. A decrease in triglycerides
was statistically significantly with respect to the doxazosin group and was close
to significance for the enalapril group. Forty-nine (62%) patients in the doxazosin
group and 43 (54%) patients in the enalapril group reported at least one adverse event.
Significant reductions in DBP after 4 weeks of treatment were achieved by both drugs,
each taken once daily. This reduction was more pronounced in the enalapril group 24
hours postdose, with a mean final daily dose of 2.8 mg of doxazosin and 12.6 mg of
enalapril. However, even relatively short-term treatment with low-dose doxazosin showed
a more favorable effect on lipids than did enalapril.
Keywords
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© 1997 Published by Elsevier Inc.
