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Abstract
The objective of this pilot study was to evaluate the effects of conjugated estrogens
on the rates of cyclic alternating patterns of sleep (CAPS) and nocturnal hot flushes
in symptomatic postmenopausal women. Seven postmenopausal or post-hysterectomy women
aged 45 to 60 years with nocturnal diaphoresis and/or hot flushes participated in
this study. The study was conducted with a single-masked design using a matching placebo.
The placebo baseline was followed by a 4-week, single-masked treatment of conjugated
estrogens 0.625 mg taken 4 hours before bedtime. Each patient's sleep was monitored
in the laboratory for 3 consecutive nights during placebo baseline and again for 3
consecutive nights after an at-home period of at least 24 days of estrogen replacement
therapy. Estrogen therapy resulted in a statistically significant decrease in the
overall number of hot flushes and the number of hot flushes associated with awakenings,
as well as improvement in sleep efficiency and a reduction in the rate of CAPS. These
data confirm earlier well-established reports that estrogens reduce the frequency
of hot flushes and suggest that the frequency of nocturnal arousals decreases and
sleep quality improves in conjunction with a reduction in the rate of CAPS.
Keywords
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© 1997 Published by Elsevier Inc.
