ABSTRACT
Purpose
The purpose of this meta-analysis was to assess the effect of statins on major adverse
cardiovascular events (MACE) related to coronary artery spasm (CAS) and to evaluate
the effectiveness of statins in patients with CAS.
Methods
A systematic search of electronic databases, including Google Scholar, the Cochrane
Central Register of Controlled Trials, and PubMed, was conducted. These studies were
all published in English, and the databases were searched from inception to July 2021.
All articles were evaluated independently by 2 researchers on the basis of inclusion
and exclusion criteria. In the research, data about the incidence of major adverse
cardiovascular events in CAS patients undergoing statin therapy was included and divided
into different subgroups. A random effects model was conducted to synthesize the data.
Findings
Five cohort studies were included in the analysis. These results indicated that statins
failed to reduce the incidence of stroke in patients with CAS in general. However,
subgroup analysis revealed that statins were more effective in improving outcomes
for CAS patients without severe coronary stenosis compared with those with severe
coronary stenosis.
Implications
Statins may have a potential benefit in patients with CAS who do not have coronary
stenosis. To investigate these findings further, future prospective, randomized controlled
research will be required.
Key words
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Article info
Publication history
Published online: June 15, 2022
Accepted:
May 15,
2022
Identification
Copyright
© 2022 Elsevier Inc.
