Hyperthyroidism is an endocrine disorder characterized by hypermetabolism and increased
excitability of multiple organs attributable to improper and excessive synthesis and
the secretion of thyroid hormones. Methimazole (MMI), one of the first-line antithyroid
drugs, is the preferred drug for hyperthyroidism therapy.
1
Long-term antithyroid drug treatment is safe and causes adverse effects in only 3%
to 5% of patients.
2
,
3
,
4
Common adverse reactions to this treatment include rash, itching, joint pain, and
transient leukopenia, which are always mild and transient.
2
,
3
,
4
Other major adverse reactions include agranulocytosis, toxic hepatitis, vasculitis,
and drug-induced lupus erythematosus.
2
,
3
,
4
Nevertheless, MMI-associated myocarditis was not mentioned in its drug assessment
and was rarely reported in previous cases. We present a case of a young male patient
who developed fever, chest discomfort, and joint symptoms after taking MMI. This patient
provided clinical and laboratory information and agreed to the case publication with
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Article info
Publication history
Published online: July 11, 2022
Accepted:
May 10,
2022
Identification
Copyright
© 2022 Elsevier Inc.
