Recurrent oral ulcer is one of the most prevalent inflammatory ulcerative disorders
of the oral mucosa. Due to the indeterminant cause and unpredictable course of the
disease, clinical treatment of patients with recurrent oral ulcer is focused on relieving
the pain, shortening the course of the disease, and prolonging the intermission period.
Numerous chemical and biologic agents have been characterized as beneficial in the
treatment of patients with recurrent oral ulcer, but there is currently no definitive
therapy available. This study aimed to investigate the clinical effects and tolerability
of combined mecobalamin tablets and vitamin E capsules in the treatment of recurrent
A total of 58 patients with recurrent oral ulcer admitted to our hospital were allocated
to receive mecobalamin tablets + vitamin E soft capsules (test group) or Fe complex
enzyme gargle only (control group) (n = 29 per group). Changes in parameters such
as pain level, as measured on a 10-point visual analog scale (VAS); ulcer status and
number of ulcers; proinflammatory cytokine levels; and quality of life, as measured
using SF-36, from before to after treatment were measured. Mean intermission time
and mean ulcer healing time were calculated. Total effectiveness rate was also calculated.
The occurrences of adverse reactions in the two groups were quantified.
The total intermission time interval was significantly longer, the mean ulcer healing
time was considerably shorter, the total number of ulcers was appreciably less, and
the total effectiveness rate was significantly greater in the test group compared
to the control group (all, P < 0.05). The VAS scores were significantly greater after treatment than before treatment
in both the test and control groups (mecobalamin + vitamin E, 2.16 [1.09] vs 7.87
[0.51]; control, 3.72 [1.15] vs 7.94 [0.56]; both, P < 0.05). Interleukin (IL)-8, tumor necrosis factor α, and C-reactive protein levels
were appreciably down-regulated in both groups when compared to before treatment.
In addition, IL-2 concentration and SF-36 scores were much greater after treatment
in the test group with respect to the control group. Levels of IL-8, TNF-α, and CRP
were significantly lesser in the test group than in the control group (all, P < 0.05).
The combination of mecobalamin tablets and vitamin E soft capsules was effective in
the treatment of recurrent oral ulcer. This combination can be used as an adjunctive
therapy, offering effective pain control and improving quality of life in patients
with oral ulcers.