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Original Research| Volume 43, ISSUE 12, e364-e376.e3, December 2021

Development of a Probiotics Practice E-Reference Database for Health Care Professionals

      Highlights

      • An online probiotics database was developed for use by healthcare professionals.
      • Database contained a total of 449 probiotic products and 584 clinical study excerpts.
      • Beta-testing was conducted among community pharmacists for feedback.
      • Overall, pharmacists were satisfied with the database and willing to use it again.
      • Database was intuitive to use and information was clear, comprehensive and useful.

      Abstract

      Purpose

      Currently available references provide evidence on the efficacy of probiotics strains but exclude product-specific information, making it challenging for health care professionals (HCPs) to provide consumers with suitable recommendations on probiotics. An online probiotics e-reference database was developed to assist HCPs in delivering evidence-based recommendations on probiotics to consumers. The usability and applicability of the database in health care practice were evaluated.

      Methods

      Information on the efficacy of probiotics and probiotic products was collated using a PubMed literature search, and from local pharmacies and online supplement stores. A web database was compiled using various programming scripts and uploaded onto a web server. The database was beta-tested using an online self-administered questionnaire for community-based pharmacists, and responses were analyzed using descriptive statistics.

      Findings

      The database comprised 584 clinical study excerpts, 449 probiotic products, and 1879 unique product-study links. Users can search for suitable probiotics based on their indication profile or for a specific probiotic product. Information provided includes the probiotic constituents, dosage regimen, and indications of the product, with supporting clinical evidence. Overall, all participants of the beta-test indicated that they were satisfied with the database and were willing to use it again (both, 13 participants [100%]). In addition, all participants indicated that they found the database intuitive to use and smooth functioning, without inconsistencies (both, 13 [100%]). The majority also indicated that they found the information provided to be clear, comprehensive, and useful in health care practice (12 [92.3%] each).

      Implications

      The probiotics e-reference database is an integrated resource that is user-friendly, and provides HCPs with ready access to clear and comprehensive information on probiotic products and clinical studies, so that HCPs can provide consumers with relevant and evidence-based recommendations on probiotics.

      Key words

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      References

        • Hill C
        • Guarner F
        • Reid G
        • Gibson GR
        • Merenstein DJ
        • Pot B
        • et al.
        The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic.
        Nature Reviews Gastroenterology & Hepatology. 2014; 11: 506-514
        • de Vrese M
        • Schrezenmeir J
        Probiotics, prebiotics, and synbiotics.
        Advances in Biochemical Engineering/Biotechnology. 2008; 111: 1-66
        • Sanders ME
        • Merenstein D
        • Merrifield CA
        • Hutkins R.
        Probiotics for human use.
        Nutrition Bulletin. 2018; 43: 212-225
        • Kopp-Hoolihan L.
        Prophylactic and therapeutic uses of probiotics: A review.
        Journal of the American Dietetic Association. 2001; 101: 229-241
      1. Probiotics Market Size, Share and Industry Analysis, 2018-2025 [Fortune Business Insights website]. Available at: https://www.fortunebusinessinsights.com/industry-reports/probiotics-market-100083. Accessed January 10, 2020.

        • McFarland LV
        • Evans CT
        • Goldstein EJC.
        Strain-specificity and disease-specificity of probiotic efficacy: A systematic review and meta-analysis.
        Frontiers in Medicine. 2018; 5: 124
        • Sniffen JC
        • McFarland LV
        • Evans CT
        • Goldstein EJC.
        Choosing an appropriate probiotic product for your patient: An evidence-based practical guide.
        PLoS One. 2018; 13e0209205
        • Rowland I
        • Capurso L
        • Collins K
        • Cummings J
        • Delzenne N
        • Goulet O
        • et al.
        Current level of consensus on probiotic science - Report of an expert meeting - London, 23 November 2009.
        Gut Microbes. 2010; 1: 436-439
        • Dietrich CG
        • Kottmann T
        • Alavi M.
        Commercially available probiotic drinks containing Lactobacillus casei DN-114001 reduce antibiotic-associated diarrhea.
        World Journal of Gastroenterology. 2014; 20: 15837-15844
      2. Probiotics and prebiotics [World Gastroenterology Organisation website]. Available at: https://www.worldgastroenterology.org/guidelines/global-guidelines/probiotics-and-prebiotics/probiotics-and-prebiotics-english. Accessed February 10, 2020.

      3. Practical Reference Guide: Probiotics in the Management of Lower GI Symptoms in Clinical Practice [European Society for Primary Care Gastroenterology website]. Available at: http://espcg.eu/wp-content/uploads/2013/09/ENGLISH-LEAFLET-ESPCG-2013-Consensus-Guidelines-on-Probiotics.pdf. Accessed May 2, 2020.

      4. Natural Medicines Database [Therapeutic Research Center Healthcare intranet database]. Available at: https://naturalmedicines.therapeuticresearch.com/. Accessed February 18, 2020.

      5. AEProbio. Clinical Guide to Probiotic Products Available in USA. Available at: http://usprobioticguide.com. Accessed January 31, 2020.

      6. AEProbio. Clinical Guide to Probiotic Products Available in Canada. Available at: http://www.probioticchart.ca. Accessed January 31, 2020.

      7. Wolters Kluwer. UpToDate. Available at: https://www.uptodate.com. Accessed February 18, 2020.

      8. IBM Watson Health. Micromedex. Available at: https://www.micromedexsolutions.com. Accessed February 18, 2020.

        • Ventola CL.
        Mobile devices and apps for health care professionals: Uses and benefits.
        P & T: A Peer-reviewed Journal for Formulary Management. 2014; 39: 356-364
        • Davies MJ
        • Collings M
        • Fletcher W
        • Mujtaba H.
        Pharmacy apps: A new frontier on the digital landscape?.
        Pharmacy Practice. 2014; 12: 453
        • Aungst TD.
        Medical applications for pharmacists using mobile devices.
        Annals of Pharmacotherapy. 2013; 47: 1088-1095
        • Mosa ASM
        • Yoo I
        • Sheets L.
        A systematic review of healthcare applications for smartphones.
        BMC Medical Informatics and Decision Making. 2012; 12: 67
      9. Petrova M, Terhaar J. The ISAPP quick guide to probiotics for health professionals: History, efficacy, and safety [ISAPP website]. Available at: https://isappscience.org/for-clinicians/resources/probiotics/. Accessed November 9, 2021.

      10. Howick J, Chalmers I, Glasziou P, Greenhalgh T, Heneghan C, Liberati A, et al. OCEBM Levels of Evidence. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence. Accessed November 9, 2021.

        • Yap KY-L
        • Chuang X
        • Lee AJM
        • Lee RZ
        • Lim L
        • Lim JJ
        • et al.
        Pharmaco-cybernetics as an interactive component of pharma-culture: Empowering drug knowledge using user-, experience- and activity-centered designs.
        International Journal of Computer Science Issues. 2009; 3: 1-13
        • Monideepa T
        • Jie Z.
        Analyzing the influence of web site design parameters on web site usability.
        Information Resources Management Journal. 2005; 18: 62-80
        • Coleman C
        • Hudson S
        • Pederson B.
        Prioritized health literacy and clear communication practices for health care professionals.
        Health Literacy Research and Practice. 2017; 1: e91-e99
        • Sackett DL
        • Straus SE.
        Finding and applying evidence during clinical rounds: The "evidence cart".
        Journal of the American Medical Association. 1998; 280: 1336-1338
        • Kwan D
        • Hirschkorn K
        • Boon H.U.S.
        Canadian pharmacists' attitudes, knowledge, and professional practice behaviors toward dietary supplements: A systematic review.
        BMC Complementary and Alternative Medicine. 2006; 6: 31
        • Wilson Z
        • Whitehead K.
        A cross sectional survey to assess healthcare professionals' attitudes to and understanding of probiotics.
        Clinical Nutrition ESPEN. 2019; 34: 104-109
        • Culverhouse SE
        • Wohlmuth H.
        Factors affecting pharmacists' recommendation of complementary medicines - A qualitative pilot study of Australian pharmacists.
        BMC Complementary and Alternative Medicine. 2012; 12: 183
        • Day RLJ
        • Harper AJ
        • Woods RM
        • Davies OG
        • Heaney LM.
        Probiotics: Current landscape and future horizons.
        Future Science OA. 2019; 5 (FSO391)