Drug Interaction With Milk and The Relevance of Acidifying/Alkalizing Nature of Food


      An interaction is a clinical event in which the effects of a drug are affected by presence of another drug, herbal, food, drink or some chemical agent. The drug–food interactions can cause changes in bioavailability and excretion of the drug may lead to treatment failure or may have beneficial effects. The aim of this study is to explore the milk interactions with certain medicines to inform healthcare professionals and patients.

      Material and Methods

      This study is classified as a secondary study, a systematic review of the literature without meta-analysis. The information was collected from electronic databases such as PubMed, Google academic and b-on, with the aid of computer software. The research was carried out with keywords like “drug Interactions”, “milk and drugs”, “interaction between the drug and milk”, among others. We selected studies published in the last 25 years and at the end were obtained 20 references relevant to the development of this article.


      The milk interferes with the absorption of various antibiotics such as tetracycline’s (decreasing absorption) and few quinolones, propranolol, mercaptopurine (reduce bioavailability), nonsteroidal anti-inflammatory drugs, digitalis, amiloride, omeprazole, spironolactone and ranitidine. The main effects of these interactions are decreased bioavailability of drugs, increase/decrease the excretion of drugs, depletion of absorption of nutrients, among others.


      As already known drug–food interactions can influence the safety and efficiency of drug therapy. The interactions between milk and drugs are mostly pharmacokinetic interactions, since the milk affects the absorption and excretion of drugs and are classified as moderate in severity because can occur a failure in the treatment and need for additional treatment. To avoid them just that medicines and milk are taken at different times. Also, having knowledge about medicines and which foods affect its therapeutic action is of utmost importance.