Abstract
Background
Technologies in which a remote trigger is used to release drug from an implanted or
injected device could enable on-demand release profiles that enhance therapeutic effectiveness
or reduce systemic toxicity. A number of new materials have been developed that exhibit
sensitivity to light, ultrasound, or electrical or magnetic fields. Delivery systems
that incorporate these materials might be triggered externally by the patient, parent
or physician to provide flexible control of dose magnitude and timing.
Objectives
To review injectable or implantable systems that are candidates for translation to
the clinic, or ones that have already undergone clinical trials. Also considered are
applicability in pediatrics and prospects for the future of drug delivery systems.
Methods
We performed literature searches of the PubMed and Science Citation Index databases
for articles in English that reported triggerable drug delivery devices, and for articles
reporting related materials and concepts.
Results
Approaches to remotely-triggered systems that have clinical potential were identified.
Ideally, these systems have been engineered to exhibit controlled on-state release
kinetics, low baseline leak rates, and reproducible dosing across multiple cycles.
Conclusions
Advances in remotely-triggered drug delivery have been brought about by the convergence
of numerous scientific and engineering disciplines, and this convergence is likely
to play an important part in the current trend to develop systems that provide more
than one therapeutic modality. Preclinical systems must be carefully assessed for
biocompatibility, and engineered to ensure pharmacokinetics within the therapeutic
window. Future drug delivery systems may incorporate additional modalities, such as
closed-loop sensing or onboard power generation, enabling more sophisticated drug
delivery regimens.
Key words
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Article info
Publication history
Accepted:
October 4,
2012
Footnotes
Publication of this supplement was supported by The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH).
Identification
Copyright
© 2012 Elsevier HS Journals, Inc. Published by Elsevier Inc. All rights reserved.
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- CorrectionClinical TherapeuticsVol. 34Issue 12
- PreviewIn the article by B. Timko and D.S. Kohane, titled “Materials to Clinical Devices: Technologies for Remotely Triggered Drug Delivery” (Clin Ther. 2012;34:S25–S35), reprinted information in Figure 4 read “Reprinted from Expert Opin Pharmacother. 10(2), Poon RT, Borys N. Lyso-thermosensitive liposomal doxorubicin: a novel approach to enhance efficacy of thermal ablation of liver cancer, 333–343.42 Copyright 2009, with permission from Elsevier.” The section should have read “Reprinted from Biomaterials.
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