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Research Article| Volume 30, SUPPLEMENT 3, S88-S89, 2008

How are biomarkers defined and validated?

  • Bryan Winchester
    Correspondence
    Address correspondence to: Bryan Winchester, PhD, Biochemistry Research Group, UCL Institute of Child Health at Great Ormond Street Hospital, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.
    Affiliations
    UCL Institute of Child Health at Great Ormond Street Hospital, London, United Kingdom
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      References

        • Biomarkers Definitions Working Group
        Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework.
        Clin Pharmacol Ther. 2001; 69: 89-95
        • Cox TM
        Biomarkers in lysosomal storage diseases: A review.
        Acta Paediatrica Suppl. 2005; 94: 39-42
        • Winchester B
        Are there useful biochemical markers of disease activity in lysosomal storage diseases.
        J Inherit Metab Dis. 2001; 24: 52-56
        • Mills K
        • Vellodi A
        • Morris P
        • et al.
        Monitoring the clinical and biochemical response to enzyme replacement therapy in three children with Fabry disease.
        Eur J Pediatr. 2004; 163: 595-603
        • Weiss DJ
        • Dorris M
        • Loh A
        • Peterson L
        Dehydrogenase based reagentless biosensor for monitoring phenylketonuria.
        Biosens Bioelectron. 2007; 22: 2436-2441
        • Boot RG
        • Verhoek M
        • de Frost M
        • et al.
        Marked elevation of the chemokine CCL18/PARC in Gaucher disease: A novel surrogate marker for assessing therapeutic intervention.
        Blood. 2004; 103: 33-39
        • Park HG
        • Ham HO
        • Kim KH
        • Huh N
        Oligonucleotide chip for the diagnosis of HNF-1 alpha mutations.
        Biosens Bioelectron. 2005; 21: 637-644
        • Smit S
        • van Breemen M
        • Hoefsloot HC
        • et al.
        Assessing the statistical validity of proteomics based biomarkers.
        Anal Chim Acta. 2007; 592: 210-217