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Abstract
Omeprazole combined with 2 antimicrobials has been suggested as a first-line option
for Helicobacter pylori eradication in recent years. However, controversy exists regarding the efficacy of
this protocol. This open-label, prospective clinical study investigated the efficacy
of omeprazolebased triple therapy for H pylori eradication in 518 patients with H pylori-positive functional dyspepsia with or without duodenal ulcer. Amoxicillin, macrolides
(clarithromycin or roxithromycin), and nitroimidazoles (metronidazole, ornidazole,
or tintdazole) were the antibiotics used in the study. Nonulcer patients were randomly
assigned to 1 of 8 different treatment protocols anu duodenal ulcer patients were
randomly assigned to 1 of 4 different treatment protocols consisting of omeprazole
(20 mg once daily for nonulcer patients, 20 mg twice daily for ulcer patients for
14 days) with a combination of 2 of the above antimicrobials (for 10 days). H pylori infection was assessed by histologic findings and a rapid urease test before therapy
and 4 weeks after therapy ended. Four hundred fifty-nine patients completed their
regimens; 327 had functional dyspepsia (180 men, 147 women; median age, 39 years;
range, 18 to 70 years) and 132 had ulcers (81 men, 51 women; median age, 40 years;
range, 18 to 70 years). Eradication of H pylori was achieved in 58.8% (270 of 459) of all patients, 58.1% (190 of 327) of nonulcer
dyspeptic patients, and 60.6% (80 of 132) of duodenal ulcer patients. The eradication
rate varied from 47.2% to 69.4% in different treatment protocols. There were no statistically
significant differences in eradication rates in any treatment group. All drugs were
generally well tolerated in all groups, and no patient discontinued treatment because
of side effects. Therapy witn omeprazole and 2 antimicrobials for H pylori had limited efficacy in a Turkish population. The reason for these results, which
conflict with those of other studies, is not clear. Further investigations of regimens
for the eradication of H pylori in our population are necessary.
Key words
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Article info
Publication history
Accepted:
July 15,
1999
Identification
Copyright
© 1999 Published by Elsevier Inc.
