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Abstract
In this multicenter, randomized, double-blind blind, placebo-controlled study, 178
patients with with symptoms of perennial allergic rhinitis (PAR) were treated with
either triamcinolone acetonide (TAA) Aqueous nasal spray (200 μg once daily) or placebo
for 4 weeks. Symptoms of PAR (nasal stuffiness, nasal discharge, sneezing, nasal index,
and nasal itching) were evaluated throughout the treatment period through the use
of patient diaries. In addition, both patients and physicians completed independent
global evaluations of treatment efficacy at the conclusion of the study. TAA Aqueous
provided clinically and statistically (P ≤ 0.05) greater improvements in nasal stuffiness, sneezing, nasal index, and nasal
itching over the 4-week study period than did placebo. Significant improvements in
sneezing (P = 0.022) were observed as early as the first day (within 12 to 16 hours based on
treatment in the morning and assessment of symptoms at bedtime), and in the nasal
index (P = 0.009) by the third day after treatment with TAA Aqueous. Patients' and physicians'
global evaluations of overall efficacy were concordant: 65% of patients rated their
nasal symptoms greatly or somewhat improved with TAA Aqueous administered once daily
was well tolerated and provided relief of PAR symptoms in adults and adolescents.
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© 1995 Published by Elsevier Inc.
