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Roxatidine (150 mg, 312 patients) was compared with ranitidine (300 mg, 308 patients) in a randomized, double-blind, parallel-group, 6-week therapeutic study for the treatment of patients with uncomplicated, benign gastric ulcer disease. The study end points (verified by using endoscopy results) were fully healed ulcers at 4 or 6 weeks. The results of roxatidine therapy were comparable to those of ranitidine therapy: healing rates of 52% and 54% at week 4 and 77% and 76% at week 6 were recorded for roxatidine and ranitidine, respectively. The drugs produced comparable reductions in ulcer diameters and decreases in abdominal pain. Adverse events associated with both roxatidine (27%) and ranitidine (28%) were headache, diarrhea, and dizziness: rash was associated in 6 of 8 cases and in only 1 case with roxatidine. In this trial, roxatidine 150 mg once daily was as efficacious and safe as ranitidine 300 mg once daily for treatment of patients with uncomplicated, benign gastric ulcer disease.
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- Peptic ulcer.in: Braunwald E Isselbacher KJ Petersdorf RG 13th ed. Harrison's Principles of Internal Medicine. McGraw-Hill, New York1994: 1363-1382
- Epidemiology, clinical manifestation and diagnosis.in: Wyngaarden JB Smith Jr, LH 19th ed. Cecil Textbook of Medicine. WB Saunders, Philadelphia1992: 656-658
- Berkow R 15th ed. The Merck Manual of Diagnosis and Therapy. Merck, Sharp & Dohme Research Laboratories, Rahwa, NJ1987
- H2-receptor antagonists—cimetidine and ranitidine.BMJ. 1983; 286: 695-697
- Drug interactions involving cimetidine—mechanisms, documentations implications.Q Rev Drug Metab Drug Interact. 1984; 5: 25-51
- Pharmacology and side effects of drugs used to treat peptic ulcers.in: Sleisenger MH Fordtran JS 3rd Ed. Gastrointestinal Disease: Pathophysiology, Diagnosis, Management. WB Saunders, Philadephia1983
- Clinical characteristics of roxatidine acetate: A review.Scand J Gastroenterol. 1988; 23 (Suppl 146): 121-134
- A review of the animal pharmacology of roxatidine acetate.Drugs. 1988; 35 (Suppl 3): 30-40
- Antisecretory effects of two new histamine H2-receptor antagonists.Arzneim-Forsch Drug Res. 1986; 36: 1358-1363
- Metabolic fate of 2-acetoxy-N-(3-(m-(1-piperidinlmethyl)phenoxl)-propyl)-acetamide hydrochloride (TZU-0460), a new H2-receptor antagonist: Effect on hepatic drug metabolizing enzyme.Pharmacometrics. 1985; 30: 357-366
- Effects of TSU-0460 on gastric acid secretion in rats and on secretagogue-induced gastric secretion in gastrict fistula dogs.Jpn Pharmacol Ther. 1985; 13: 255-262
- Cimetidine: A review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.Drugs. 1978; 15: 93-131
- Ranitidine: A review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases.Drugs. 1982; 24: 267-303
- A comparison of roxatidine acetate and ranitidine in gastric ulcer healing.Drugs. 1988; 35 (Suppl 3): 120-126
- A comparison of roxatidine acetate 150 mg once daily and 75 mg twice daily in gastric ulcer healing.Drugs. 1988; 35 (Suppl 3): 127-133
- A comparison of roxatidine acetate 150 mg once daily and 75 mg twice daily in duodenal ulcer healing.Drugs. 1988; 35 (Supp 3): 96-101
- A comparison of roxatidine acetate and ranitidine in duodenal ulcer healing.Drugs. 1988; 35 (Suppl 3): 90-95
- Effect of smoking on duodenal ulcer healing with cimetidine and oxmetidine.Gut. 1982; 23: 866-871
© 1995 Published by Elsevier Inc.