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Abstract
In this pilot study, 12 patients (6 men, 6 postmenopausal women) with hypercholesterolemia
were treated with low-dose (5 mg/d) simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme
A reductase inhibitor, for 4 weeks. Low-density lipoprotein (LDL) samples were isolated
at the beginning (week 0) and at the end (week 4) of the treatment regimen. Simvastatin
caused significant decreases of total cholesterol (−18.1%), LDL cholesterol (−27.6%),
and apolipoprotein B (−21.8%), and significantly reduced total cholesterol, free cholesterol,
cholesterol esters, phospholipids, and protein in LDL without significantly changing
the component ratios and fatty acid levels of LDL. However, simvastatin therapy had
no major effects on either antioxidant levels in LDL or the oxidative susceptibility
of LDL. We conclude that low-dose simvastatin significantly reduces LDL cholesterol
levels without increasing the oxidative susceptibility of LDL or decreasing the antioxidant
levels of LDL, and thus may reduce the risk of coronary artery disease.
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© 1995 Published by Elsevier Inc.
