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Abstract
The clinical efficacy and tolerability of sodium hyaluronate, a high—molecular-weight
hyaluronic acid preparation, in the treatment of patients with periarthritis of the
shoulder was investigated in a multicenter, cooperative study. Of 70 patients seen
at 12 participating centers between April and September 1992, follow-up was possible
in 62 (28 men and 34 women; mean age, 65.4 years). Patients received sodium hyaluronate
25 mg (1% solution in an ampule) once weekly for 5 weeks by injection into the glenoid
cavity or the subacromial bursa. If periarthritis resolved during this period, treatment
was stopped; if periarthritis had not fully resolved by the end of the 5 weeks, weekly
or biweekly treatment was continued as appropriate. The mean treatment period was
8.16 ± 0.88 weeks, and the mean total administered dose was 6.05 ± 0.61 ampules. Rates
of improvement over pretreatment values were 75.0% for pain at rest, 73.7% for pain
on motion, and 78.8% for pain on pressure. Significant increases in joint angles (measured
as components of joint range of motion after administration of sodium hyaluronate)
were observed; activities of daily living also improved significantly (P < 0.05 to P < 0.001). No adverse reactions were observed. These results strongly suggest that
sodium hyaluronate is an effective agent for the treatment of patients with pariarthritis
of the shoulder.
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© 1995 Published by Elsevier Inc.
