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Abstract
The recurrence rate of gastric ulcers healing to a white scar is low, whereas that
of ulcers healing to a red scar is high. Teprenone is a mucosal protective agent that
can promote epithelial regeneration by increasing the mucosal hexosamine content.
It promotes white scar formation when administered as maintenance therapy for ulcers.
A nationwide, multicenter study was performed to determine whether white scar formation
was also promoted when teprenone was used during initial therapy. Analysis of the
data from 1249 patients showed that teprenone significantly promoted white scar formation.
The presence of severe ulcers (large size and active stage), ulcer location at the
gastric angulus, and smoking retarded white scar formation irrespective of the use
of teprenone.
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© 1995 Published by Elsevier Inc.
