Clinical Studies| Volume 17, ISSUE 5, P852-860, September 1995

Download started.


Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain

      This paper is only available as a PDF. To read, Please Download here.


      This single-dose, double-blind, parallel-group, single-site study compared ibuprofen lysine 400 mg with acetaminophen 1000 mg and placebo in 240 patients with moderate-to-severe postoperative dental pain. The relative onset of analgesic response, overall analgesic efficacy, duration of effect, and safety were assessed over a 6-hour postdose period. Analgesic efficacy was assessed by patient self-rating of pain intensity, pain relief, time to meaningful pain relief, need for additional analgesic medication, and patient global evaluation. Both ibuprofen lysine 400 mg and acetaminophen 1000 mg were significantly (P ≤ 0.05) more effective than placebo. Ibuprofen lysine had a significantly (P ≤ 0.05) faster onset of action with greater peak and overall analgesic effect than did acetaminophen. All treatments were generally well tolerated.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinical Therapeutics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Geisslinger G
        • Dietzel K
        • Bezler H
        • et al.
        Therapeutically relevant differences in the pharmacokinetic and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid.
        Int J Clin Pharmacol Ther Toxicol. 1989; 27: 324-328
        • Geisslinger G
        • Menzel S
        • Wissel K
        • Brune K
        Single dose pharmacokinetics of different formulations of ibuprofen and aspirin.
        Drug Invest. 1993; 5: 238-242
        • Beaver WT
        • Forbes JA
        • Barkaszi BA
        • et al.
        An evaluation of ibuprofen and acetaminophen in postoperative oral surgery pain.
        Clin Pharmacol Ther. 1987; 41 (Abstract): 180
        • Mehlisch DR
        • Sollecito WA
        • Helfrick JF
        • et al.
        Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain.
        J Am Dent Assoc. 1990; 121: 257-263
        • Cooper SA
        Five studies on ibuprofen for postsurgical dental pain.
        Am J Med. 1984; 77: 70-77
        • Cooper SA
        • Reynolds DC
        • Gallegos LT
        • et al.
        A PK/PD study of ibuprofen formulations.
        Clin Pharmacol Ther. 1994; 55 (Abstract): 126
        • Nelson SL
        • Brahim JS
        • Korn SH
        • et al.
        Comparison of single-dose ibuprofen lysine, acetylsalicylic acid, and placebo for moderate-to-severe postoperative dental pain.
        Clin Ther. 1994; 16: 458-465
        • Furey SA
        • Waksman JA
        • Dash BH
        Non-prescription ibuprofen: Side effect profile.
        Pharmacotherapy. 1992; 12: 403-407