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Abstract
This study evaluated physicians' use of the occurrence of tinnitus as a tool to establish
the optimal dosage of salsalate, a nonacetylated salicylate, in patients with arthritis
treated in routine clinical practice. The use of printed educational materials to
improve compliance was also studied prospectively. A total of 782 patients were enrolled
in this 3-week study by 95 general practitioners in an office setting. Of the 771
assessable patients, 90.0% had osteoarthritis, 9.7% had rheumatoid arthritis, and
0.3% had both types of arthritis. Most patients experienced improvement of symptoms
after 3 weeks of treatment. There were no differences in the rates of improvement
at the first and third weeks of treatment between patients with osteoarthritis and
patients with rheumatoid arthritis. In addition, duration of arthritis had no effect
on rates of improvement. Rates of patient satisfaction tended to increase over the
study period. Rates of patient satisfaction did not differ significantly at the first
and third weeks between patients who did receive printed educational materials and
those who did not. Treatment was discontinued in 234 patients (30.4%) because of side
effects. The most frequent reasons for discontinuation were gastrointestinal symptoms
(n = 102; 13.2%) and tinnitus (n = 52; 6.7%). The clinical effectiveness and safety
of salsalate were confirmed in patients with arthritis in routine clinical practice
settings.
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© 1995 Published by Elsevier Inc.
