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Abstract
The effects of long-term cilazapril treatment on glucose and lipid metabolism were
assessed in 25 hypertensive patients with non—insulin-dependent diabetes mellitus
(NIDDM). Patients were treated with 0.5 to 1 mg of cilazapril once daily or a combination
of cilazapril and other anti-hypertensive drugs once daily for 48 weeks. Both systolic
and diastolic blood pressures were significantly reduced (P < 0.001) throughout the study with no significant changes in heart rate and no adverse
effects such as cough. There were no significant changes in body mass index or serum
levels of glycated hemoglobin A1c, fructosamine, total cholesterol, triglycerides, lipoproteins (high-density lipoprotein
cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein
cholesterol), or apolipoproteins (apo A-I, apo C-II, apo C-III, apo B, and apo E).
Cilazapril caused a significant increase (P < 0.05) in levels of apo A-II and a significant decrease (P < 0.05) in the apo B:apo A-I ratio, an index of arteriosclerosis. These results suggest
that cilazapril has favorable effects on glucose and lipid metabolism and that it
may be useful as the first or second choice of antihypertensive drugs in hypertensive
patients with NIDDM.
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© 1995 Published by Elsevier Inc.
