This paper is only available as a PDF. To read, Please Download here.
Abstract
Patients with chronic active hepatitis C show low lipoprotein(a) (Lp[a]) values. We
studied the changes in Lp(a) levels caused by treatment with interferon in 24 patients
(9 men and 15 women; mean age, 56.8 ± 7.3 years) affected by chronic active hepatitis
C. Fifteen healthy subjects (6 men and 9 women; mean age, 57.4 ± 10.3 years) were
used as controls. All of the patients with chronic hepatitis C were treated with intramuscular
interferon, 3 million units 3 times per week for 6 months. These patients had lower
baseline serum Lp(a) concentrations than the controls (4.8 ± 3.8 mg/dL vs 13.4 ± 10.3
mg/dL, respectively; P = 0.0007). A significant increase in Lp(a) levels (6.6 ± 7.2 mg/dL; P = 0.05) occurred after 6 months of treatment in patients with chronic active hepatitis
C. Only complete responders presented a significant increase in Lp(a) values (P = 0.01). We believe that increased Lp(a) levels represent an expression of improved
liver functions.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical TherapeuticsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Treatment of chronic non-A, non-B hepatitis with recombinant human alpha-IFN: A preliminary report.NEJM. 1986; 315: 1575-1578
- Virus interference. The Interferon.Proc R Soc London B Biol Sci. 1957; 147: 258-267
- Low dose interferon in the treatment of hairy cell leukemia.J Natl Cancer Inst. 1989; 81: 1172-1179
- Interferons: Therapeutic potential in cutaneous diseases.Adv Dermatol. 1991; 6: 3-34
- Combination therapy with interleukin 2 and alpha interferon for the treatment of patients with advanced cancer.J Clin Oncol. 1989; 7: 1863-1869
- Interferon-induced antiviral actions and their regulation.Adv Virus Res. 1993; 42: 57-61
- Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells.Biochem Res Commun. 1983; 112: 537-541
- Interferon-γ inhibits stimulated adrenocorticotropin, prolactin and growth hormone secretion in normal rat anterior pituitary cell cultures.Endocrinology. 1990; 126: 2919-2927
- Elevated plasma cortisol levels during interferon-γ treatment.Immunopharmacology. 1989; 17: 141-148
- In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis.Endocrinology. 1992; 131: 1695-1702
- Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3t3-L1 cells.J Immunol. 1986; 135: 3969-3971
- A new serum type system in man The Lp(a) system.Acta Pathol Microbiol Immunol Scand. 1963; 59: 369-382
- Lipoprotein (a): Structure, properties and possible involvement in thrombogenesis and atherogenesis.Atherosclerosis. 1990; 85: 1-14
- Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction.Atherosclerosis. 1986; 59: 199-204
- Lp(a) in subjects with active chronic hepatitis.Atherosclerosis. 1994; 110 (Abstract): S101
- Lp(a) lipoprotein, pre-beta1 lipoprotein in Swedish middle aged males and in patients with coronary heart disease.Clin Genet. 1975; 7: 334-341
- A dominant role of lipoprotein (a) in the investigation and evaluation of parameters indicating the development of cervical atherosclerosis.Atherosclerosis. 1985; 58: 187-198
- Lipoprotein (a): A risk factor with novel mechanism for the development of atherothrombotic disease.in: Mazzaferri EJ Bav RS Kreisberg RA Advances in Endocrinology and Metabolism. 3. Mosby Yearbook, Chicago1992: 237-257
- Human apolipoprotein B (apo B) mRNA: Identification of two distinct apo (B) mRNAs, an mRNA with the apo B-100 sequence and an apo B mRNA containing a premature in-frame translational stop codon, in both liver and intestine.Proc Natl Acad Sci USA. 1988; 85: 1772-1776
- Rainwater DJ. Apolipoprotein (a) [apo (a)] glycoprotein isoforms result from size differences in apo (a) mRNA in baboons.J Biol Chem. 1989; 264: 6013-6016
- Changes of genetic apolipoprotein phenotypes caused by liver transplantation: Implications for apolipoprotein synthesis.J Clin Invest. 1989; 83: 137-142
- cDNA sequence of human apolipoprotein (a) is homologous to plasminogen.Nature. 1987; 330: 132-137
- Rhesus monkey apoprotein (a). Sequence, evolution and sites of synthesis.J Biol Chem. 1989; 264: 5957-5965
- Turnover of lipoprotein (a) in man.J Clin Invest. 1980; 65: 1483-1490
- Studies on the metabolism of the lipoprotein Lp(a) in man.Atherosclerosis. 1978; 30: 57-65
- Lipoprotein (a) in cirrhosis.BMJ. 1992; 304: 545-546
- Prognostic value of Lp(a) in cirrhosis of the liver.Atherosclerosis. 1994; 110 (Abstract): S101
- Lp(a) lipoprotein as a risk factor for myocardial infarction.JAMA. 1986; 256: 2540-2544
Article info
Identification
Copyright
© 1995 Published by Elsevier Inc.
