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Abstract
The effects of long-term treatment with nipradilol, a nitroester-containing beta-blocker,
on casual and 24-hour blood pressures were studied in 70 patients with mild-to-moderate
essential hypertension. Antihypertensive effects of nipradilol on casual blood pressure
were observed in 68% of patients. Nipradilol reduced pulse rates, but no bradycardia
was observed. The usefulness of nipradilol in the present study was 65%. The results
of ambulatory blood pressure monitoring indicated that nipradilol reduced systolic
blood pressure more than diastolic blood pressure, and reduced blood pressure during
waking more than during sleep. These results suggest that nipradilol is a safe and
useful long-term antihypertensive drug in both young and older patients with mild-to-moderate
essential hypertension. When administered twice daily, nipradilol is effective throughout
a 24-hour period.
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© 1995 Published by Elsevier Inc.
