This paper is only available as a PDF. To read, Please Download here.
This study used Medicaid claims data from Pennsylvania to examine the costs and effects of changing calcium channel blocker therapies. Specifically, we compared Procardia XL® with Adalat® CC. They are the only once-daily—dosed, extended-release forms of nifedipine available. These drugs were interesting to compare for several reasons. First, because the frequency of treatment regimens has been shown to be the most important determinant of long-term compliance with calcium channel blocker medications, it was desirable to compare drugs having identical dosing regimens. Second, switching from one to the other should be quite feasible in most patients. Third, Adalat CC is priced (ie, average wholesale price) less than Procardia XL. The results indicate that prescription prices were lower when patients were switched from Procardia XL to Adalat CC, with no apparent effects on blood pressure control, the incidence of adverse drug reactions, or nonprescription health care costs. The potential savings to Medicaid from switching patients from Procardia XL to Adalat CC appears to be large, more than $2.5 million annually for Procardia XL-treated Medicaid patients in the state of Pennsylvania. Our study also demonstrates that large retrospective databases can be used to evaluate economic and clinical outcomes for specific therapy alternatives. Such evaluations are increasingly relevant to third-party payers, health maintenance organizations, and other parties involved in managed care.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Clinical Therapeutics
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Long-term patient compliance with prescribed regimens of calcium channel blockers.Clin Ther. 1994; 16: 316-326
- aBrouch KL Bowers CR Aaron WS St. Anthony's ICD-9-CM Code Book. St. Anthony Publishing, Inc, Reston, Va1994: 88
- bBrouch KL Bowers CR Aaron WS St Anthony's ICD-9-CM Code Book. St. Anthony Publishing, Inc, Reston, Va1994: 146
- cBrouch KL Bowers CR Aaron WS St Anthony's ICD-9-CM Code Book. St. Anthony Publishing, Inc, Reston, Va1994: 166
- dBrouch KL Bowers CR Aaron WS St Anthony's ICD-9-CM Code Book. St. Anthony Publishing, Inc, Reston, Va1994: 223
- eBrouch KL Bowers CR Aaron WS St Anthony's ICD-9-CM Code Book. St. Anthony Publishing, Inc, Reston, Va1994: 251-256
- Physicians' Current Procedural Terminology. American Medical Association, Chicago, Ill1992
- Statistical Abstract of the United States, 1991. 1991 (Washington, DC) 111th edition.
- Health economics and outcomes research with retrospective data.Clin Ther. 1994; 16: 1063-1067
- Olin BR Hebel SK Dombek CE Gremp JL Facts and Comparisons. Facts and Comparisons, Inc, St Louis1994: 149i, j
- The efficacy and safety of once-daily nifedipine coat-core in the treatment of mild-to-moderate hypertension.Clin Ther. 1993; 15: 963-975
© 1995 Published by Elsevier Inc.