| Pharmacotherapy |
| New Drug Review |
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Velaglucerase Alfa for the Management of Type 1 Gaucher Disease
24 January 2012
Abstract: Background: Gaucher disease (GD) is the most common lysosomal storage disease, (frequency of 1:40,000 to 1:60,000). Ninety-Five percent of patients have type 1 (nonneuropathic type). Symptom...
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Jennifer L. Morris
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259-271
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| Review Articles |
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Author(s) |
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Dasatinib: From Treatment of Imatinib-Resistant or -Intolerant Patients With Chronic Myeloid Leukemia to Treatment of Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
30 January 2012
Abstract: Background: Imatinib is an effective treatment for patients with newly diagnosed chronic phase chronic myeloid leukemia (CML-CP), but resistance to imatinib can occur. Second-generation BCR-...
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Brian L. Abbott
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272-281
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A Network Meta-Analysis on the Efficacy of Serotonin Type 3 Receptor Antagonists Used in Adults During the First 24 Hours for Postoperative Nausea and Vomiting Prophylaxis
02 February 2012
Abstract: Background: The serotonin type 3 receptor antagonists (5-HT3 antagonists) ondansetron, granisetron, tropisetron, and dolasetron are potential prophylactic agents for patients with mild to mo...
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Derek H. Tang,
Daniel C. Malone
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282-294
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| Original Research |
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A Meta-Analysis of the Effects of Interleukin-6 −174 G>C Genetic Polymorphism on Acute Graft-Versus-Host Disease Susceptibility
03 February 2012
Abstract: Background: The interleukin-6 (IL-6) −174 G>C genetic polymorphism has been implicated to play an important role in acute graft-versus-host disease (aGVHD). However, previous studies have...
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Boyoon Choi,
Dong Eun Lee,
Hyo Young Park,
Sohyun Jeong,
Sang-Min Lee,
Eunhee Ji,
Seonyang Park,
Jung Mi Oh
et al.
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295-304
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Pharmacokinetic Comparison of 2 Formulations of Anastrozole (1 mg) in Healthy Korean Male Volunteers: A Randomized, Single-Dose, 2-Period, 2-Sequence, Crossover Study
27 January 2012
Abstract: Background: Anastrozole is an aromatase inhibitor used to treat advanced breast cancer in postmenopausal women. A generic 1-mg tablet of anastrozole was recently developed. Objective: The st...
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Yook-Hwan Noh,
Young-Ju Ko,
Sang-Heon Cho,
Jong-Lyul Ghim,
Sangmin Choe,
Jin Ah Jung,
Un-Jib Kim,
Seok-Joon Jin,
Hyun-Jung Park,
Geun-Seog Song,
Hyeong-Seok Lim,
Kyun-Seop Bae
et al.
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305-313
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Efficacy and Safety of Additional 200-mg Dose of Celecoxib in Adult Patients With Postoperative Pain Following Extraction of Impacted Third Mandibular Molar: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Study in Japan
30 January 2012
Abstract: Background: Although third mandibular molar extraction is a widely used and validated model of acute pain for evaluating analgesic efficacy, a large proportion of patients experience moderat...
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Ken‘ichi Saito,
Akihiro Kaneko,
Katsuyuki Machii,
Hiroyoshi Ohta,
Masayuki Ohkura,
Makoto Suzuki
et al.
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314-328
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Intra-anal Iferanserin 10 mg BID for Hemorrhoid Disease: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
13 January 2012
Abstract: Background: Despite the prevalence of internal hemorrhoid disease (HD), there are few pharmacologic options. Iferanserin, a selective serotonin receptor antagonist, is being studied for use ...
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Alexander Herold,
John Dietrich,
Roger Aitchison
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329-340
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Long-Term Persistence With the Immunomodulatory Drugs for Multiple Sclerosis: A Retrospective Database Study
02 February 2012
Abstract: Background: Immunomodulatory drugs (IMDs) for multiple sclerosis (MS) have been available in Canada since 1995 and are currently the most commonly prescribed treatment for MS. However, relat...
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Charity Evans,
Jennifer Tam,
Elaine Kingwell,
Joel Oger,
University of British Columbia MS Clinic Neurologists,
Helen Tremlett
et al.
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341-350
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Evaluation of Gabapentin Enacarbil on Cardiac Repolarization: A Randomized, Double-Blind, Placebo- and Active-Controlled, Crossover Thorough QT/QTc Study in Healthy Adults
Abstract: Background: Gabapentin enacarbil, a transported prodrug of gabapentin, was recently approved by the US Food and Drug Administration for the treatment of moderate to severe restless legs synd...
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Dan Chen,
Ritu Lal,
Katie Zomorodi,
Harisha Atluri,
Judy Ho,
Wendy Luo,
James Tovera,
Daniel Bonzo,
Kenneth Cundy
et al.
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351-362.e3
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Atomoxetine Treatment Outcomes in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: Results From a Post Hoc, Pooled Analysis
30 January 2012
Abstract: Background: Many children with attention-deficit/hyperactivity disorder (ADHD) continue to experience this disorder as adults, which may, in part, be due to the discontinuity of health care ...
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Lenard A. Adler,
Timothy Wilens,
Shuyu Zhang,
Ralf W. Dittmann,
Deborah N. D'Souza,
Leslie Schuh,
Todd M. Durell
et al.
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363-373
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Effect of Statins on Total Cholesterol Concentrations, Cardiovascular Morbidity, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study
16 January 2012
Abstract: Background: The benefit of statin use on total cholesterol (TC) concentration has not been studied previously in patients with chronic obstructive pulmonary disease (COPD). Objective: Our st...
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Xia Sheng,
Michael J. Murphy,
Thomas M. MacDonald,
Stuart Schembri,
William Simpson,
Janet Winter,
John H. Winter,
Li Wei
et al.
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374-384
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| Commentaries |
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Two Decades of Experience With the Haemophilus influenzae Serotype b Conjugate Vaccine in the United Kingdom
16 January 2012
Abstract: Background: The Haemophilus influenzae serotype b (Hib) conjugate vaccine was introduced into the UK national childhood immunization program in 1992 after clinical trials reported the vaccin...
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Shamez N. Ladhani
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385-399
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Biosimilars: Impact of Biologic Product Life Cycle and European Experience on the Regulatory Trajectory in the United States
16 January 2012
Abstract: Background: Biosimilars are defined as biologic products that are highly similar to reference products, notwithstanding minor differences in clinically inactive components, with no clinicall...
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Islah Ahmed,
Ben Kaspar,
Uma Sharma
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400-419
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| Brief Report |
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Metabolism, Excretion, and Pharmacokinetics of [14C]-Radiolabeled Aleglitazar: A Phase I, Nonrandomized, Open-Label, Single-Center, Single-Dose Study in Healthy Male Volunteers
16 January 2012
Abstract: Background: Aleglitazar is a dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist with a balanced activity (similar half-maximal effective concentrations) toward PPAR-α and -γ ...
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Stefan Sturm,
Michael Seiberling,
Idelette Weick,
Axel Paehler,
Christoph Funk,
Thorsten Ruf
et al.
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420-429
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| Pharmaceutical Economics & Health Policy |
| Editorial |
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Price and Value: The Pharmacoeconomics of Scarcity
Pharmaceutical shortages threaten clinical care outcomes and third-party payer, government, and personal finances, yet these shortages are not routinely considered in pharmacoeconomic analyses.
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Alan Lyles
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432-433
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| Review Article |
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Efficacy of Bypassing Agents in Patients With Hemophilia and Inhibitors: A Systematic Review and Meta-Analysis
30 January 2012
Abstract: Background: Activated prothrombin complex concentrate (aPCC) and recombinant Factor VIIa (rFVIIa) are 2 bypassing agents commonly used for treating acute bleeds in hemophiliac patients with ...
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Zheng-Yi Zhou,
Joel W. Hay
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434-445
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| Original Research |
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Cost-Effectiveness Analysis of Ranibizumab versus Verteporfin Photodynamic Therapy, Pegaptanib Sodium, and Best Supportive Care for the Treatment of Age-Related Macular Degeneration in Greece
30 January 2012
Abstract: Background: Age-related macular degeneration (AMD) is a progressive disease that results in loss of central vision, significant functional impairment, and a subsequent heavy socioeconomic bu...
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Kostas Athanasakis,
Vasilios Fragoulakis,
Vasiliki Tsiantou,
Panagiotis Masaoutis,
Nikolaos Maniadakis,
John Kyriopoulos
et al.
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446-456
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Factors Associated With the Initiation of Disease-Modifying Antirheumatic Drugs in Newly Diagnosed Rheumatoid Arthritis: A Retrospective Claims Database Study
30 January 2012
Abstract: Objectives: The objectives of this study were to quantify the proportion of US patients with newly diagnosed rheumatoid arthritis (RA) in whom disease-modifying antirheumatic drug (DMARD) th...
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Machaon M.K. Bonafede,
Kathleen M. Fox,
Barbara H. Johnson,
Crystal Watson,
Shravanthi R. Gandra
et al.
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457-467
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Costs of Trastuzumab in Combination With Chemotherapy for HER2-Positive Advanced Gastric or Gastroesophageal Junction Cancer: An Economic Evaluation in the Chinese Context
Abstract: Background: Adding trastuzumab to a conventional regimen of chemotherapy can improve survival in patients with human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or ga...
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Bin Wu,
Ming Ye,
Huafeng Chen,
Jinfang F. Shen
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468-479
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| Pharmacokinetics, Bioavailability, & Bioequivalence |
| Original Research |
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Tolerability and Pharmacokinetics of a New P-Glycoprotein Inhibitor, HM30181, in Healthy Korean Male Volunteers: Single- and Multiple-Dose Randomized, Placebo-Controlled Studies
30 January 2012
Abstract: Background: HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. Objective: The objective of this study was to investigat...
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Tae-Eun Kim,
Namyi Gu,
Seo Hyun Yoon,
Joo-Youn Cho,
Kyung-Mi Park,
Sang-Goo Shin,
In-Jin Jang,
Kyung-Sang Yu
et al.
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482-494
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| Pediatric, Adolescent, & Maternal Therapeutics |
| Original Research |
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Pharmacokinetics and Safety Profile of Tigecycline in Children Aged 8 to 11 Years With Selected Serious Infections: A Multicenter, Open-Label, Ascending-Dose Study
16 January 2012
Abstract: Background: Tigecycline, a broad-spectrum antibiotic used for treating serious bacterial infections in adults, may be suitable for pediatric use once an appropriate dosage is determined. Obj...
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Jay Purdy,
Sylvie Jouve,
Jean Li Yan,
Ivana Balter,
Nathalie Dartois,
C. Angel Cooper,
Joan Korth-Bradley
et al.
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496-507.e1
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| Correction |
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Correction
20 January 2012
In the article “Incidence of Cardiovascular Events in Which 2 Thiazolidinediones Are Used as Add-on Treatments for Type 2 Diabetes Mellitus in a Taiwanese Population” (Clin Ther. 2011;33:1904–1913), t...
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508
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