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Clinical Therapeutics
Volume 34, Issue 1
, Pages 1-13
, January 2012
Fidaxomicin: The Newest Addition to the Armamentarium Against Clostridium difficile Infections
References
-
Dificid [package insert]
.
San Diego, Calif: Optimer Pharmaceutics; 2011;
- A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and the epidemiology of C. difficile-associated disease in Quebec . Clin Infect Dis . 2007;44:238–244
- . Emergence of Clostridium difficile-associated disease in North America and Europe . Clin Microbiol Infect . 2006;12(Suppl 6):2–18
- A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality . N Engl J Med . 2005;353:2442–2449
- . Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003 . Emerg Infect Dis . 2006;12:409–415
- A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use . Infect Control Hosp Epidemiol . 2005;26:273–280
-
Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008
.
Euro Surveill
. 2008;13:1–7
- . Disease associated with Clostridium difficile infection . Ann Intern Med . 1989;110:255–257
- . Clostridium difficile: its disease and toxins . Clin Microbiol Rev . 1988;1:1–18
- . Review of Clostridium difficile-associated diseases . Am J Infect Control . 1986;14:99–109
- Clostridium difficile colitis in the critically ill . Dis Colon Rectum . 1996;39:619–623
- Factors associated with prolonged symptoms and severe disease due to Clostridium difficile . Age Ageing . 1999;28:107–113
- Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure . Infect Control Hosp Epidemiol . 2007;28:123–130
- Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile . Clin Infect Dis . 2002;34:346–353
- Prevalence and characteristics of bacteria and host factors in an outbreak situation of antibiotic-associated diarrhoea . J Med Microbiol . 2005;54:149–153
- . Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism . Clin Infect Dis . 1994;18(Suppl 4):S265–S272
-
.
Clostridium difficile-related hospitalizations among US adults, 2006
.
Emerg Infect Dis
. 2009;15:122–124
- The emerging infectious challenge of Clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences . Infect Control Hosp Epidemiol . 2007;28:1219–1227
- An epidemic, toxin gene-variant strain of Clostridium difficile . N Engl J Med . 2005;353:2433–2441
- Prevalence and characterization of a binary toxin (actin-specific adp-ribosyltransferase) from Clostridium difficile . J Clin Microbiol . 2004;42:1933–1939
- Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe . Lancet . 2005;366:1079–1084
- Health care-associated clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian nosocomial infection surveillance program study . Clin Infect Dis . 2009;48:568–576
- Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) . Infect Control Hosp Epidemiol . 2010;31:431–455
-
Vancocin [package insert]
. Exton, Pa: ViroPharma, Inc; 2005;
- Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity . CMAJ . 2004;171:466–472
- A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity . Clin Infect Dis . 2007;45:302–307
-
Louie T., Gerson M., Grimard D., et al. Results of a phase III trial comparing tolevamer, vancomycin and metronidazole in Clostridium difficile-Associated Diarrhea (CDAD). Abstract presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17–20, 2007; Chicago, Ill.
- Emergence of reduced susceptibility to metronidazole in Clostridium difficile . J Antimicrob Chemother . 2008;62:1046–1052
- Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease . Antimicrob Agents Chemother . 2008;52:2403–2406
- Skin and environmental contamination with vancomycin-resistant enterococci in patients receiving oral metronidazole or oral vancomycin treatment for Clostridium difficile-associated disease . Infect Control Hosp Epidemiol . 2009;30:13–17
- . New antibiotics for selective treatment of gastrointestinal infection caused by Clostridium difficile . Expert Opin Ther Pat . 2010;20:1389–1399
- . Efficacy of rifaximin and vancomycin combination therapy in a patient with refractory Clostridium difficile-associated diarrhea . J Clin Gastroenterol . 2007;41:932–933
- Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection . Clin Infect Dis . 2009;48:1732–1735
- Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin . Clin Infect Dis . 2007;44:846–848
- Clinical outcomes of intravenous immune globulin in severe Clostridium difficile-associated diarrhea . Am J Infect Control . 2007;35:131–137
- . Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease . Am J Gastroenterol . 2002;97:1769–1775
- Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide . J Antimicrob Chemother . 2007;59:705–710
- Management and outcomes of a first recurrence of Clostridium difficile-associated disease in Quebec, Canada . Clin Infect Dis . 2006;42:758–764
-
Lipiarmycin, a new antibiotic from actinoplanes
(Isolation, chemical, biological and biochemical characterization)
.
J Antibiot
. 1975;28:253–259
-
.
Lipiarmycin, a new antibiotic from actinoplanes
(Description of the producer strain and fermentation studies)
.
J Antibiot
. 1975;28:247–252
-
Lipiarmycin, a new antibiotic from actinoplanes
(Mechanism of Action)
.
J Antibiot
. 1975;28:543–549
- Mutation in the bacillus subtilis RNA polymerase beta' subunit confers resistance to lipiarmycin . Antimicrob Agents Chemother . 2006;50:401–402
-
.
Inhibition by lipiarmycin of bacteriophage growth in Bacillus subtilis
.
J Virol
. 1980;33:945–953
- In vitro activity of OPT-80 against Clostridium difficile . Antimicrob Agents Chemother . 2004;48:2280–2282
- Postantibiotic effect of fidaxomicin and its major metabolite (OP-1118) against Clostridium difficile . Antimicrob Agents Chemother . 2011;55:4427–4429
-
Babakhani F., Robert N., Shangle S., et al. Antimicrobial activity and post-antibiotic effect (PAE) of OPT-80, a new macrocyclic compound, against Clostridium difficile. Abstract presented at: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 29 -November 2, 2004; Washington, DC.
-
Babakhani F., Seddon J., Robert N., et al. Narrow spectrum activity and low fecal protein binding of OPT-80 and its major hydrolysis metabolite (OP-1118). Abstract presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Ill.
- Typing and susceptibility of bacterial isolates from the fidaxomicin (OPT-80) phase II study for C. difficile infection . Anaerobe . 2009;15:234–236
- . Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species . Antimicrob Agents Chemother . 2004;48:4430–4434
- In vitro activities of OPT-80 and comparator drugs against intestinal bacteria . Antimicrob Agents Chemother . 2004;48:4898–4902
- In vitro activities of 15 antimicrobial agents against 110 toxigenic Clostridium difficile clinical isolates collected from 1983 to 2004 . Antimicrob Agents Chemother . 2007;51:2716–2719
-
Karlowsky J.A., Laing N.M., Alfa M., et al. In vitro antimicrobial activities of OPT-80, rifaximin, tigecycline, and comparators against toxin-positive Clostridium difficile cultured from diarrheal stool specimens. Abstract presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17- 20, 2007; Chicago, Ill.
- Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile . J Med Microbiol . 2011;60:1213–1217
- In vitro activity of fidaxomicin (OPT-80) tested against contemporary clinical isolates of Staphylococcus spp. and Enterococcus spp . Antimicrob Agents Chemother . 2010;54:2273–2275
- OPT-80 eliminates Clostridium difficile and is sparing of bacteroides species during treatment of C (difficile infection) . Antimicrob Agents Chemother . 2009;53:261–263
-
Nerandzic M.M., Mullane K.M., Miller M.A., et al. Acquisition and overgrowth of vancomycin-resistant enterococci in patients treated with either fidaxomicin (FDX) or vancomycin (VAN) for Clostridium difficile infection. Abstract presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 12-15, 2009; San Francisco, Calif.
-
Babakhani F., Shangle S., Robert N., et al. Resistance development, crossresistance, and synergy studies of OPT-80. Abstract presented at: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 29-November 2, 2004; Washington, DC.
-
Miller M., Mastrantonio P., Blanchette R., et al. Rifampin, rifaximin, OPT-80 and tigecycline susceptibility of C. difficile strains from Canada and Italy. Abstract presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 12-15, 2009; San Francisco, Calif.
- In vitro and in vivo evaluation of tiacumicins b and c against Clostridium difficile . Antimicrob Agents Chemother . 1991;35:1108–1111
- Safety, tolerance, and pharmacokinetic studies of OPT-80 in healthy volunteers following single and multiple oral doses . Antimicrob Agents Chemother . 2008;52:1391–1395
- Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection . Antimicrob Agents Chemother . 2009;53:223–228
-
Louie T., Miller M., Crook D., et al. Effect of advancing age on outcomes of therapy for Clostridium difficile infection. Abstract presented at: Annual Scientific Meeting of the American Geriatrics Society; May 11-14, 2011; Washington, DC.
-
Crook D., Weiss K., Cornely O.A., et al. Randomized clinical trial in Clostridium difficile infection confirms equivalent cure rate and lower recurrence rate of fidaxomicin versus vancomycin. Abstract presented at: 20th European Congress of Clinical Microbiology and Infectious Diseases, April 10-13, 2010; Vienna, Austria.
-
Mullane K., Golan Y., Crook D., et al. Renal impairment and response to fidaxomicin versus vancomycin in patients with clostridium difficile infection. Abstract presented at: 49th Annual meeting of the Infectious Diseases Society of America; October 20-23, 2011; Boston, Mass.
- Fidaxomicin versus vancomycin for Clostridium difficile infection . N Engl J Med . 2011;364:422–431
-
Cheknis A.K., Citron D.M., Nagaro K.J., et al. Epidemic BI/NAP1 is the dominant strain of Clostridium difficile found in patients in the OPT-80 vs. Vancomycin clinical trial in North American and the European Union. Abstract presented at: 48th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 25-28, 2008; Washington, DC.
-
Golan Y., Mullane K.M., Miller M.A., et al. Low recurrence rate among patients with C. difficile infection (CDI) treated with fidaxomicin (FDX). Abstract presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 12-15, 2009; San Francisco, Calif.
-
Gorbach S., Weiss K., Sears P., et al. Safety of fidaxomicin versus vancomycin in treatment of Clostridium difficile infection. Abstract presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 12-15, 2009; San Francisco, Calif.
- Comparative susceptibilities of fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two fidaxomicin phase III trials of Clostridium difficile infection . Antimicrob Agents Chemother . 2011;55:5194–5199
- Efficacy of fidaxomicin versus vancomycin as therapy for Clostridium difficile infection in individuals taking concomitant antibiotics for other concurrent infections . Clin Infect Dis . 2011;53:440–447
-
Okumu F., Walsh R.B., Sears P., et al. Safety and pharmacokinetics of OPT- 80, a novel antibiotic for treatment of Clostridium difficile associated diarrhea (CDAD). Abstract presented at: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 29-November 2, 2004; Washington, DC.
-
Drug Topics Red Book
. Montvale, NJ: Thompson Medical Economics; 2011;
PII: S0149-2918(11)00838-1
doi: 10.1016/j.clinthera.2011.12.003
© 2012 Elsevier HS Journals, Inc. All rights reserved.
Next »
Clinical Therapeutics
Volume 34, Issue 1
, Pages 1-13
, January 2012
