Clinical Therapeutics
Volume 34, Issue 1 , Pages 14-23 , January 2012

Head Lice and the Use of Spinosad

  • Susan C. Villegas, PharmD

      Affiliations

    • Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York
    • The Children's Hospital at Montefiore, Bronx, New York
    • Corresponding Author InformationAddress for correspondence: Susan C. Villegas, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, 75 Dekalb Avenue, Brooklyn, NY 11201
    • ,
  • Robin L. Breitzka, PharmD

      Affiliations

    • Children's Medical Center, Dallas, Texas

,Accepted 21 November 2011.

References 

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  3. Hansen RC , O'Haver J . Economic considerations associated with Pediculus humanus capitis infestation . Clin Pediatr (Phila) . 2004;43:523–527
  4. Abdel-Ghaffar F , Semmler M , Al-Rasheid K , et al.  Comparative in vitro tests on the efficacy and safety of 13 anti-head-lice products . Parasitol Res . 2010;106:423–429
  5. Frankowski BL , Weiner LB  Committee on School Health and Committee on Infectious Diseases, American Academy of Pediatrics . Head lice . Pediatrics . 2002;110:638–643
  6. American Academy of Pediatrics, Committee on School Health and Committee on Infectious Diseases . Pediculosis capitis (Head Lice) . In:  Pickering LK ,  Backer CJ ,  Kimberlin DW ,  Long SS editor. Red Book: 2009 Report of the Committee on Infectious Diseases . 28th ed.. Elk Grove Village, Ill: American Academy of Pediatrics; 2009;p. 495–497
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  10. Meinking TL , Villar ME , Vicaria M , et al.  The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (Pediculosis humanus capitis) . Pediatr Dermatol . 2010;27:19–24
  11. Downs A . Managing head lice in an era of increasing resistance to insecticides . Am J Clin Dermatol . 2004;5:169–177
  12. Vontas J , Hejazi M , Hemingway J , et al.  Resistance-associated point mutations of organophosphate insensitive acetylcholinesterase, in the olive fruit fly Bactrocera oleae . Insect Mol Biol . 2002;11:329–336
  13. Meinking TL , Vicaria M , Eyerdam DH , et al.  Efficacy of a reduced application time of Ovide lotion (0.5% malathion) compared to Nix creme rinse (1% permethrin) for the treatment of head lice . Pediatr Dermatol . 2004;21:670–674
  14. Natroba [package insert] . Carmel, Ind: ParaPRO LLC; 2011;
  15. Kirst HA . The spinosyn family of insecticides: realizing the potential of natural products research . J Antibiot (Tokyo) . 2010;63:101–111
  16. Kirst HA , Creemer LC , Naylor SA , et al.  Evaluation and development of spinosyns to control ectoparasites on cattle and sheep . Curr Top Med Chem . 2002;2:675–699
  17. Cueto GM , Zerba E , Picollo MI . Embryonic development of human lice: rearing conditions and susceptibility to spinosad . Mem Inst Oswaldo Cruz . 2006;101:257–261
  18. Stough D , Shellabarger S , Quiring J , Gabrielsen AA . Efficacy and safety of spinosad and permethrin creme rinses for pediculosis capitis (head lice) . Pediatrics . 2009;124:e389–e395
  19. Sparks TC , Crouse GD , Durst G . Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids . Pest Manag Sci . 2001;57:896–905
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  28. Ovide [package insert] . Hawthorne, NY: TaroPharma; 2005;
  29. White WH , Hutchens DE , Jones C , et al.  Therapeutic and persistent efficacy of spinosad applied as a pour-on or a topical spray against natural infestations of chewing and sucking lice on cattle . Vet Parasitol . 2007;143:329–336

PII: S0149-2918(11)00781-8

doi: 10.1016/j.clinthera.2011.11.026

Clinical Therapeutics
Volume 34, Issue 1 , Pages 14-23 , January 2012

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