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Pharmacokinetic Comparison of 2 Formulations of Anastrozole (1 mg) in Healthy Korean Male Volunteers: A Randomized, Single-Dose, 2-Period, 2-Sequence, Crossover Study
27 January 2012
Yook-Hwan Noh, Young-Ju Ko, Sang-Heon Cho, Jong-Lyul Ghim, Sangmin Choe, Jin Ah Jung, Un-Jib Kim, Seok-Joon Jin, Hyun-Jung Park, Geun-Seog Song, Hyeong-Seok Lim, Kyun-Seop Bae
Background: Anastrozole is an aromatase inhibitor used to treat advanced breast cancer in postmenopausal women. A generic 1-mg tablet of anastrozole was recently developed. Objective: The study was de...
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Velaglucerase Alfa for the Management of Type 1 Gaucher Disease
24 January 2012
Jennifer L. Morris
Background: Gaucher disease (GD) is the most common lysosomal storage disease, (frequency of 1:40,000 to 1:60,000). Ninety-Five percent of patients have type 1 (nonneuropathic type). Symptomatic patie...
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Erratum
20 January 2012
In the article “Incidence of Cardiovascular Events in Which 2 Thiazolidinediones Are Used as Add-on Treatments for Type 2 Diabetes Mellitus in a Taiwanese Population” (Clin Ther. 2011;33:1904–1913), t...
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Effect of Statins on Total Cholesterol Concentrations, Cardiovascular Morbidity, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: A Population-Based Cohort Study
16 January 2012
Xia Sheng, Michael J. Murphy, Thomas M. MacDonald, Stuart Schembri, William Simpson, Janet Winter, John H. Winter, Li Wei
Background: The benefit of statin use on total cholesterol (TC) concentration has not been studied previously in patients with chronic obstructive pulmonary disease (COPD). Objective: Our study aimed ...
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Pharmacokinetics and Safety Profile of Tigecycline in Children Aged 8 to 11 Years with Selected Serious Infections: A Multicenter, Open-Label, Ascending-Dose Study
16 January 2012
Jay Purdy, Sylvie Jouve, Jean Li Yan, Ivana Balter, Nathalie Dartois, C. Angel Cooper, Joan Korth-Bradley
Background: Tigecycline, a broad-spectrum antibiotic used for treating serious bacterial infections in adults, may be suitable for pediatric use once an appropriate dosage is determined. Objective: Th...
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